Selected PanTHERA Publications

  1. Investigating the Solubility and Activity of a Novel Class of Ice Recrystallization Inhibitors
    Ampaw A.A.; Newell, K.; Ben, R.N. Investigating the Solubility and Activity of a Novel Class of Ice Recrystallization Inhibitors. Processes 9: 1781-1791 (2021).
  1. The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low-cost technique for ex vivo subnormothermic lung perfusion.
    Lautner, L., Himmata, S., Acker, J.P. and Nagendran, J. The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low-cost technique for ex vivo subnormothermic lung perfusion. Cryobiology 97: 93-100 (2020).
  1. Cryoprotectant-dependent control of intracellular ice recrystallization in hepatocytes using small molecule carbohydrate inhibitors.
    William, N. and Acker, J.P. Cryoprotectant-dependent control of intracellular ice recrystallization in hepatocytes using small molecule carbohydrate inhibitors Cryobiology 97: 123-130 (2020).
  1. Characterizing the ability of an ice recrystallization inhibitor to improve platelet cryopreservation.
    Waters, L., Ben, R., Acker, J.P., Padula, M.P., Marks, D.C. and Johnson, L. Characterizing the ability of an ice recrystallization inhibitor to improve platelet cryopreservation. Cryobiology 96: 152-158 (2020)
  1. Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives.
    William, N. and Acker, J.P. Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives. Cryobiology 97: 250-253 (2020).
  1. Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment.
    Jahan, S., Adam, M.K., Manesia, J.K., Doxtator, E., Ben, R.N. and Pineault, N. Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment. Transfusion 60: 769-778 (2020).
  1. Modulating intracellular ice growth with cell permeating small molecule ice recrystallization inhibitors.
    Poisson, J.S., Acker, J.P., Briard, J.G., Meyer, J.E. and Ben, R.N. Modulating intracellular ice growth with cell permeating small molecule ice recrystallization inhibitors. Langmuir 35 (23): 7452-7458 (2019).
  1. Hydroxyethyl starch supplemented with ice recrystallization inhibitors greatly improves cryopreservation of human red blood cells.
    Poisson, J., Briard, J., Turner, T.R., Acker, J.P. and Ben, R. Hydroxyethyl starch supplemented with ice recrystallization inhibitors greatly improves cryopreservation of human red blood cells. BioProcessing Journal 15 (4): 16-21 (2017).
  1. O-Aryl-glycoside ice recrystallization inhibitors as novel cryo-protectants – A structure-function study.
    Capicciotti, C., Mancini, R., Turner, T.R., Koyama, T., Alteen, M., Doshi, M., Inada, T., Acker, J.P. and Ben, R. O-Aryl-glycoside ice recrystallization inhibitors as novel cryo-protectants – A structure-function study. ACS Omega 1: 656-662 (2016).
  1. Small molecule ice recrystallization inhibitors mitigate cellular damage during freezing, transient warming and thawing.
    Briard, J.G., Poisson, J.S., Turner, T.R., Acker, J.P. and Ben, R.N. Small molecule ice recrystallization inhibitors mitigate cellular damage during freezing, transient warming and thawing. Nature Scientific Reports 6: 23619 (2016).
  1. QSAR accelerated discovery of potent ice recrystallization inhibitors.
    Briard, J.G., Fernandez, M., De Luna, P., Woo, T.K. and Ben, R.N. QSAR accelerated discovery of potent ice recrystallization inhibitors. Nature Scientific Reports. 6: 26403 (2016).
  1. Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells.
    Briard, J.G., Jahan, S., Chandran, P., Allan, D., Pineault, N. and Ben, R.N. Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells. ACS Omega 1 (5): 1010-1018 (2016).
  1. Small ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations.
    Capicciotti, C.J., Tchir, J.D.R., Turner, T., Mancini, R.S., Acker, J.P. and Ben, R.N. Small ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations. Nature Scientific Reports 5: 9692 (2015).
  1. Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors.
    Tonelli, D., Capicciotti, C.J., Doshi, M. and Ben, R.N. Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors. RSC Advances 5: 21728 (2015).
  1. Quantitative analysis of the efficacy and potency of novel small molecule ice recrystallization inhibitors.
    Abraham, S., Keillor, K., Capicciotti, C.J., Perley-Robertson, E., Keillor, J.W. and Ben, R.N. Quantitative analysis of the efficacy and potency of novel small molecule ice recrystallization inhibitors. Crystal Growth & Design 15: 5034-5039 (2015).
  1. Designing ice recrystallization inhibitors: From antifreeze (glyco)proteins to small molecules.
    Balcerzak, A.K., Capicciotti, C.J., Briard, J.G. and Ben, R.N. Designing ice recrystallization inhibitors: From antifreeze (glyco)proteins to small molecules. RSC Advances 4: 42682 (2014).
  1. Assessing the ability of a short-fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization.
    Chaytor, J.L. and Ben, R.N. Assessing the ability of a short-fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization. Bioorganic & Medicinal Chemistry Letters 20 (17): 5251-5254 (2010).
  1. First Report of Successful Laser Warming for Frozen Gonadal Tissues and Oocytes in the Domestic Cat Model.
    Rowlison T, Nagashima J, Acker JP, Ben R, Daly J, Hagedorn M, Comizzoli P. First Report of Successful Laser Warming for Frozen Gonadal Tissues and Oocytes in the Domestic Cat Model. Biopreservation and biobanking. 10.1089/bio.2022.0071. Advance online publication. https://doi.org/10.1089/bio.2022.0071 (2022)

News & Events

Scientist Feature: Dr Fay Betsou, Director, Biological Resource Center of Institut Pasteur (CRBIP)

Ever wondered what biobanking means or what it entails? PanTHERA CryoSolutions sat down with Dr. Fay Betsou, from the Biological...
Read More
Scientist Feature: Dr Fay Betsou, Director, Biological Resource Center of Institut Pasteur (CRBIP)

Scientist Feature: Dr. Robert Ben, Co-Founder and Chief Scientific Officer

PanTHERA CryoSolutions sat down with Dr. Robert Ben, Chief Scientific Officer of PanTHERA CryoSolutions to hear his thoughts on cryopreservation...
Read More
Scientist Feature: Dr. Robert Ben, Co-Founder and Chief Scientific Officer

What are some of the challenges in cryopreservation?

What are some of the challenges in cryopreservation? Biopreservation is a process by which the degradation of biologics is suppressed...
Read More
What are some of the challenges in cryopreservation?

Protected: Scientist Feature: Dr Erik Woods, Chief Science Officer, Co-Founder of Ossium Health

This content is password protected. To view it please enter your password below: Password:
Read More
Protected: Scientist Feature: Dr Erik Woods, Chief Science Officer, Co-Founder of Ossium Health

What are some of the applications of cryopreservation?

What are some of the applications of cryopreservation? Cryopreservation refers to the storage of biological material at low temperatures, and...
Read More
What are some of the applications of cryopreservation?

Scientist Feature: Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions

We sat down with Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions and understood the motivations behind embarking on...
Read More
Scientist Feature: Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions

What is Cryopreservation?

What is Cryopreservation? Cryopreservation uses very low temperatures to preserve living cells and structurally intact tissues. While this imagery evokes...
Read More
What is Cryopreservation?

Recovery and reproduction of an Antarctic tardigrade retrieved from a moss sample frozen for over 30 years

Read More
Recovery and reproduction of an Antarctic tardigrade retrieved from a moss sample frozen for over 30 years

Vitrifying multiple embryos in different arrangements does not alter the cooling rate

Read More
Vitrifying multiple embryos in different arrangements does not alter the cooling rate

A Novel Iterative Fitting Method

Read More
A Novel Iterative Fitting Method