Selected PanTHERA Publications

  1. Improved cryopreservation of human induced pluripotent stem cell (iPSC) and iPSC derived neurons using ice-recrystallization inhibitors. Alasmar S, Huang J, Chopra K, Baumann E, Aylsworth A, Hewitt M, Sandhu J, Tauskela J S, Ben R, Jezierski A. Stem Cells 41(11):1006-1021 (2023). https://doi.org/10.1093/stmcls/sxad059
  1. Probing the Mechanism of Action of Small-Molecule Ice Recrystallization Inhibitors Using Proton Nuclear Magnetic Resonance Relaxation. McMunn L, D’Costa AS, Bordenave N, Ben R. J Phys Chem Lett 14(26): 6043-6050 (2023) 
  1. Taking lessons from nature to improve cell therapy cryopreservation. William N, Coatham M, and Acker JP. Cell and Gene Therapy Insights 9(2): 255-264 (2023).
  1. Engineered Compounds to Control Ice Nucleation and Recrystallization. William N, Mangan S, Acker JP, Ben R. Annual Review of Biomedical Engineering 25: 333-362 (2023).
  1. First Report of Successful Laser Warming for Frozen Gonadal Tissues and Oocytes in the Domestic Cat Model
    Rowlison T, Nagashima J, Acker JP, Ben R, Daly J, Hagedorn M, Comizzoli P. Biopreservation and biobanking http://doi.org/10.1089/bio.2022.0071 Published Online (2022)
  1. Investigating the Solubility and Activity of a Novel Class of Ice Recrystallization Inhibitors
    Ampaw A.A.; Newell, K.; Ben, R.N. Processes 9: 1781-1791 (2021).
  1. The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low-cost technique for ex vivo subnormothermic lung perfusion.
    Lautner, L., Himmata, S., Acker, J.P. and Nagendran, J. Cryobiology 97: 93-100 (2020).
  1. Transient loss in membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers. William N, and Acker JP. Cryobiology 97: 217-221 (2020). 
  1. Cryoprotectant-dependent control of intracellular ice recrystallization in hepatocytes using small molecule carbohydrate inhibitors.
    William, N. and Acker, J.P.  Cryobiology 97: 123-130 (2020).
  1. Characterizing the ability of an ice recrystallization inhibitor to improve platelet cryopreservation.
    Waters, L., Ben, R., Acker, J.P., Padula, M.P., Marks, D.C. and Johnson, L.  Cryobiology 96: 152-158 (2020)
  1. Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives.
    William, N. and Acker, J.P. Cryobiology 97: 250-253 (2020).
  1. Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment.
    Jahan, S., Adam, M.K., Manesia, J.K., Doxtator, E., Ben, R.N. and Pineault, N. Transfusion 60: 769-778 (2020).
  1. Modulating intracellular ice growth with cell permeating small molecule ice recrystallization inhibitors.
    Poisson, J.S., Acker, J.P., Briard, J.G., Meyer, J.E. and Ben, R.N. Langmuir 35 (23): 7452-7458 (2019).
  1. Hydroxyethyl starch supplemented with ice recrystallization inhibitors greatly improves cryopreservation of human red blood cells.
    Poisson, J., Briard, J., Turner, T.R., Acker, J.P. and Ben, R.  BioProcessing Journal 15 (4): 16-21 (2017).
  1. O-Aryl-glycoside ice recrystallization inhibitors as novel cryo-protectants – A structure-function study.
    Capicciotti, C., Mancini, R., Turner, T.R., Koyama, T., Alteen, M., Doshi, M., Inada, T., Acker, J.P. and Ben, R. ACS Omega 1: 656-662 (2016).
  1. Small molecule ice recrystallization inhibitors mitigate cellular damage during freezing, transient warming and thawing.
    Briard, J.G., Poisson, J.S., Turner, T.R., Acker, J.P. and Ben, R.N. Nature Scientific Reports 6: 23619 (2016).
  1. QSAR accelerated discovery of potent ice recrystallization inhibitors.
    Briard, J.G., Fernandez, M., De Luna, P., Woo, T.K. and Ben, R.N. Nature Scientific Reports. 6: 26403 (2016).
  1. Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells.
    Briard, J.G., Jahan, S., Chandran, P., Allan, D., Pineault, N. and Ben, R.N. ACS Omega 1 (5): 1010-1018 (2016).
  1. Small ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations.
    Capicciotti, C.J., Tchir, J.D.R., Turner, T., Mancini, R.S., Acker, J.P. and Ben, R.N. Nature Scientific Reports 5: 9692 (2015).
  1. Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors.
    Tonelli, D., Capicciotti, C.J., Doshi, M. and Ben, R.N. Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors. RSC Advances 5: 21728 (2015).
  1. Quantitative analysis of the efficacy and potency of novel small molecule ice recrystallization inhibitors.
    Abraham, S., Keillor, K., Capicciotti, C.J., Perley-Robertson, E., Keillor, J.W. and Ben, R.N. Crystal Growth & Design 15: 5034-5039 (2015).
  1. Designing ice recrystallization inhibitors: From antifreeze (glyco)proteins to small molecules.
    Balcerzak, A.K., Capicciotti, C.J., Briard, J.G. and Ben, R.N. RSC Advances 4: 42682 (2014).
  1. Assessing the ability of a short-fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization.
    Chaytor, J.L. and Ben, R.N. Bioorganic & Medicinal Chemistry Letters 20 (17): 5251-5254 (2010).

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