Selected PanTHERA Publications
- Improved cryopreservation of human induced pluripotent stem cell (iPSC) and iPSC derived neurons using ice-recrystallization inhibitors Huang Improved cryopreservation of human induced pluripotent stem cell (iPSC) and iPSC derived neurons. Stem Cells (2023). https://doi.org/10.1093/stmcls/sxad059
- Probing the Mechanism of Action of Small-Molecule Ice Recrystallization Inhibitors Using Proton Nuclear Magnetic Resonance Relaxation. McMunn L, D’Costa AS, Bordenave N, Ben R. Probing the Mechanism of Action of Small-Molecule Ice Recrystallization Inhibitors Using Proton Nuclear Magnetic Resonance Relaxation. J Phys Chem Lett 14(26): 6043-6050 (2023).
- Taking lessons from nature to improve cell therapy cryopreservation. William N, Coatham M, and Acker JP. Taking lessons from nature to improve cell therapy cryopreservation. Cell and Gene Therapy Insights 9(2): 255-264 (2023).
- Engineered Compounds to Control Ice Nucleation and Recrystallization. William N, Mangan S, Acker JP, Ben R. Engineered Compounds to Control Ice Nucleation. Annual Review of Biomedical Engineering 25: 333-362 (2023).
- First Report of Successful Laser Warming for Frozen Gonadal Tissues and Oocytes in the Domestic Cat Model
Rowlison T, Nagashima J, Acker JP, Ben R, Daly J, Hagedorn M, Comizzoli P. First Report of Successful Laser Warming for Frozen Gonadal Tissues and Oocytes in the Domestic Cat Model. Biopreservation and biobanking http://doi.org/10.1089/bio.2022.0071 Published Online (2022)
- Investigating the Solubility and Activity of a Novel Class of Ice Recrystallization Inhibitors
Ampaw A.A.; Newell, K.; Ben, R.N. Investigating the Solubility and Activity of a Novel Class of Ice Recrystallization Inhibitors. Processes 9: 1781-1791 (2021).
- The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low-cost technique for ex vivo subnormothermic lung perfusion.
Lautner, L., Himmata, S., Acker, J.P. and Nagendran, J. The efficacy of ice recrystallization inhibitors in rat lung cryopreservation using a low-cost technique for ex vivo subnormothermic lung perfusion. Cryobiology 97: 93-100 (2020).
- Transient loss in membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers. William N, and Acker JP. Transient loss in membrane integrity following intracellular ice formation in dimethyl sulfoxide-treated hepatocyte and endothelial cell monolayers. Cryobiology 97: 217-221 (2020).
- Cryoprotectant-dependent control of intracellular ice recrystallization in hepatocytes using small molecule carbohydrate inhibitors.
William, N. and Acker, J.P. Cryoprotectant-dependent control of intracellular ice recrystallization in hepatocytes using small molecule carbohydrate inhibitors Cryobiology 97: 123-130 (2020).
- Characterizing the ability of an ice recrystallization inhibitor to improve platelet cryopreservation.
Waters, L., Ben, R., Acker, J.P., Padula, M.P., Marks, D.C. and Johnson, L. Characterizing the ability of an ice recrystallization inhibitor to improve platelet cryopreservation. Cryobiology 96: 152-158 (2020)
- Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives.
William, N. and Acker, J.P. Control of ice recrystallization in liver tissues using small molecule carbohydrate derivatives. Cryobiology 97: 250-253 (2020).
- Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment.
Jahan, S., Adam, M.K., Manesia, J.K., Doxtator, E., Ben, R.N. and Pineault, N. Inhibition of ice recrystallization during cryopreservation of cord blood grafts improves platelet engraftment. Transfusion 60: 769-778 (2020).
- Modulating intracellular ice growth with cell permeating small molecule ice recrystallization inhibitors.
Poisson, J.S., Acker, J.P., Briard, J.G., Meyer, J.E. and Ben, R.N. Modulating intracellular ice growth with cell permeating small molecule ice recrystallization inhibitors. Langmuir 35 (23): 7452-7458 (2019).
- Hydroxyethyl starch supplemented with ice recrystallization inhibitors greatly improves cryopreservation of human red blood cells.
Poisson, J., Briard, J., Turner, T.R., Acker, J.P. and Ben, R. Hydroxyethyl starch supplemented with ice recrystallization inhibitors greatly improves cryopreservation of human red blood cells. BioProcessing Journal 15 (4): 16-21 (2017).
- O-Aryl-glycoside ice recrystallization inhibitors as novel cryo-protectants – A structure-function study.
Capicciotti, C., Mancini, R., Turner, T.R., Koyama, T., Alteen, M., Doshi, M., Inada, T., Acker, J.P. and Ben, R. O-Aryl-glycoside ice recrystallization inhibitors as novel cryo-protectants – A structure-function study. ACS Omega 1: 656-662 (2016).
- Small molecule ice recrystallization inhibitors mitigate cellular damage during freezing, transient warming and thawing.
Briard, J.G., Poisson, J.S., Turner, T.R., Acker, J.P. and Ben, R.N. Small molecule ice recrystallization inhibitors mitigate cellular damage during freezing, transient warming and thawing. Nature Scientific Reports 6: 23619 (2016).
- QSAR accelerated discovery of potent ice recrystallization inhibitors.
Briard, J.G., Fernandez, M., De Luna, P., Woo, T.K. and Ben, R.N. QSAR accelerated discovery of potent ice recrystallization inhibitors. Nature Scientific Reports. 6: 26403 (2016).
- Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells.
Briard, J.G., Jahan, S., Chandran, P., Allan, D., Pineault, N. and Ben, R.N. Small-molecule ice recrystallization inhibitors improve the post-thaw function of hematopoietic stem and progenitor cells. ACS Omega 1 (5): 1010-1018 (2016).
- Small ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations.
Capicciotti, C.J., Tchir, J.D.R., Turner, T., Mancini, R.S., Acker, J.P. and Ben, R.N. Small ice recrystallization inhibitors enable freezing of human red blood cells with reduced glycerol concentrations. Nature Scientific Reports 5: 9692 (2015).
- Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors.
Tonelli, D., Capicciotti, C.J., Doshi, M. and Ben, R.N. Inhibiting gas hydrate formation using small molecule ice recrystallization inhibitors. RSC Advances 5: 21728 (2015).
- Quantitative analysis of the efficacy and potency of novel small molecule ice recrystallization inhibitors.
Abraham, S., Keillor, K., Capicciotti, C.J., Perley-Robertson, E., Keillor, J.W. and Ben, R.N. Quantitative analysis of the efficacy and potency of novel small molecule ice recrystallization inhibitors. Crystal Growth & Design 15: 5034-5039 (2015).
- Designing ice recrystallization inhibitors: From antifreeze (glyco)proteins to small molecules.
Balcerzak, A.K., Capicciotti, C.J., Briard, J.G. and Ben, R.N. Designing ice recrystallization inhibitors: From antifreeze (glyco)proteins to small molecules. RSC Advances 4: 42682 (2014).
- Assessing the ability of a short-fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization.
Chaytor, J.L. and Ben, R.N. Assessing the ability of a short-fluorinated antifreeze glycopeptide and a fluorinated carbohydrate derivative to inhibit ice recrystallization. Bioorganic & Medicinal Chemistry Letters 20 (17): 5251-5254 (2010).
News & Events
Revolutionizing Agriculture: The Crucial Role of Cryopreservation
By Elizabeth Tan
/ 23 November 2023
Revolutionizing Agriculture: The Crucial Role of Cryopreservation In the ever-evolving landscape of agriculture, advancements in technology continue to shape the...
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The Vital Role of Ice Recrystallization Inhibitors in Cold Chain Management
By Elizabeth Tan
/ 23 November 2023
The Vital Role of Ice Recrystallization Inhibitors in Cold Chain Management In the world of logistics and supply chain management,...
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Ice Recrystallization Inhibitors: A Promising Breakthrough in Cryopreservation
By Elizabeth Tan
/ 26 July 2023
Ice Recrystallization Inhibitors: A Promising Breakthrough in Cryopreservation Cryopreservation, the process of preserving biological materials at extremely low temperatures, is...
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PanTHERA CryoSolutions Press Coverage
By Elizabeth Tan
/ 21 July 2023
PanTHERA CryoSolutions is honoured to be featured in various news outlets across the country. These articles are a testament to...
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GlycoNet and PanTHERA CryoSolutions’ Journey: From Bench to Bedside
By Elizabeth Tan
/ 16 July 2023
GlycoNet and PanTHERA CryoSolutions’ Journey: From Bench to Bedside PanTHERA CryoSolutions is a Canadian corporation that designs and manufactures cryopreservation...
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PanTHERA CryoSolutions Awarded Grant from Alberta Innovates in support of Groundbreaking Research in Cryopreservation Technology
By Elizabeth Tan
/ 7 July 2023
PanTHERA CryoSolutions is pleased to announce that it has been awarded $180,616 in grant funding with the Accelerating Innovations into...
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What is transient warming and how does it affect cryopreservation?
By Elizabeth Tan
/ 20 June 2023
What is transient warming and how does it affect cryopreservation? Cryopreservation is a process of preserving biological materials such as...
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PanTHERA CryoSolutions receives funding to support research and development project
By Elizabeth Tan
/ 7 March 2023
PanTHERA CryoSolutions is pleased to announce that it is receiving advisory services and up to $395,700 in funding from the...
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How are Cryoprotective Agents (CPAs) used in cryopreservation?
By Elizabeth Tan
/ 28 February 2023
How are Cryoprotective Agents (CPAs) used in cryopreservation? Cryopreservation is a key enabling technology used in many industries and having...
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What does thawing look like in cryopreservation?
By Elizabeth Tan
/ 14 February 2023
What does thawing look like in cryopreservation? The freezing and thawing of cells is a technique that has been used...
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