The PanTHERA Difference

Reducing Cryopreservation Damage

PanTHERA’s ice recrystallization inhibitors (IRIs) increase overall post-thaw cell recovery and quality by reducing damage throughout the cryopreservation process. Our IRIs are proven to be more effective in comparison to commercially  available cryopreservation solutions.

Reducing Toxicity of Conventional Cryoprotectants

Our IRIs permit the use of lower amounts of conventional Cryoprotective Agents (CPA) resulting in higher post-thaw viability and recovery.  CPA compounds are toxic and can damage the cells they are meant to preserve. By adding IRIs to existing cryopreservation solutions, we significantly reduce the cell damage resulting from the toxic effects of glycerol, dimethyl sulfoxide (DMSO) and hydroxyethyl starch (HES), the primary CPAs used in cell preservation.

Reducing Damage from Transient Warming

PanTHERA’s product reduces damage from transient warming occurring during cell banking and shipping. Transient warming is a significant concern as it can negatively affect cells and their ability to function properly. PanTHERA’s IRIs protect cells from the damage associate with temperature fluctuations during cryostorage leading to improved post-thaw viability and recovery as well as enhanced functionality.

Improving the Stability of Frozen Cells

PanTHERA improves the stability of frozen cells thus permitting storage over a broader range of temperatures. Liquid nitrogen storage systems can be prohibitively expensive to operate.  Since IRIs enable higher sub-zero storage of cryopreserved samples, they can significantly reduce the cost of banking cell inventories. Higher sub-zero storage simplifies the transportation of cells and extended storage within conventional freezers with no need for liquid nitrogen or use of special shipping containers.

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The PanTHERA Difference

Reducing Cryopreservation Damage

PanTHERA’s ice recrystallization inhibitors (IRIs) increase overall post-thaw cell recovery and quality by reducing damage throughout the cryopreservation process. Our IRIs are proven to be more effective in comparison to commercially  available cryopreservation solutions.

Reducing Toxicity of Conventional Cryoprotectants

Our IRIs permit the use of lower amounts of conventional Cryoprotective Agents (CPA) resulting in higher post-thaw viability and recovery.  CPA compounds are toxic and can damage the cells they are meant to preserve. By adding IRIs to existing cryopreservation solutions, we significantly reduce the cell damage resulting from the toxic effects of glycerol, dimethyl sulfoxide (DMSO) and hydroxyethyl starch (HES), the primary CPAs used in cell preservation.

Reducing Damage from Transient Warming

PanTHERA’s product reduces damage from transient warming occurring during cell banking and shipping. Transient warming is a significant concern as it can negatively affect cells and their ability to function properly. PanTHERA’s IRIs protect cells from the damage associate with temperature fluctuations during cryostorage leading to improved post-thaw viability and recovery as well as enhanced functionality.

Improving the Stability of Frozen Cells

PanTHERA improves the stability of frozen cells thus permitting storage over a broader range of temperatures. Liquid nitrogen storage systems can be prohibitively expensive to operate.  Since IRIs enable higher sub-zero storage of cryopreserved samples, they can significantly reduce the cost of banking cell inventories. Higher sub-zero storage simplifies the transportation of cells and extended storage within conventional freezers with no need for liquid nitrogen or use of special shipping containers.

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Benefits

Improved Performance

PanTHERA’s IRIs improve post-thaw recovery and functionality of cells which can positively impact research and potentially enhance clinical patient outcomes. In addition to its use in stabilizing cell and gene therapies for medical applications, our IRI technology can be used across several areas that include assisted reproductive technologies, animal and aquaculture husbandry, cell-based diagnostics, and biopharmaceutical production. Our novel IRI technology opens numerous opportunities for scientists and laboratories to explore.

Significant Cost Reductions

PanTHERA IRI technology reduces operational costs including logistics and shipping. In certain applications, IRIs allow for higher sub-zero storage of samples reducing the cost of cell banking inventories.

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Benefits

Improved Performance

PanTHERAs IRI’s improve post-thaw recovery and functionality of cells which can positively impact research and potentially enhance clinical patient outcomes. In addition to its use in stabilizing cell and gene therapies for medical applications, our IRI technology can be used across several areas that include assisted reproductive technologies, animal and aquaculture husbandry, cell-based diagnostics, and biopharmaceutical production. Our novel IRI technology opens numerous opportunities for scientists and laboratories to explore.

Significant Cost Reductions

PanTHERA IRI technology reduces operational costs including logistics and shipping. In certain applications, IRIs allow for higher sub-zero storage of samples reducing the cost of cell banking inventories.

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Applications

PanTHERA’s technology to control ice recrystallization is a platform technology that can be applied across multiple application areas. The following provides insight into some of the initial applications of our novel technology.

  • Research and development
  • Gene and cell therapy products
  • Organ, tissue, and blood banking
  • Biomanufacturing industry (such as viral vectors, oncolytic virus, recombinant proteins, vaccines)
  • Assisted reproductive technologies
  • Animal and aquaculture-specific breeding and preservation
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Applications

PanTHERA’s technology to control ice recrystallization is a platform technology that can be applied across multiple application areas. The following provides insight into some of the initial applications of our novel technology.

  • Research and development
  • Gene and cell therapy products
  • Organ, tissue, and blood banking
  • Biomanufacturing industry (such as viral vectors, oncolytic virus, recombinant proteins, vaccines)
  • Assisted reproductive technologies
  • Animal and aquaculture-specific breeding and preservation
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News & Events

Scientist Feature: Dr Fay Betsou, Director, Biological Resource Center of Institut Pasteur (CRBIP)

Ever wondered what biobanking means or what it entails? PanTHERA CryoSolutions sat down with Dr. Fay Betsou, from the Biological...
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Scientist Feature: Dr Fay Betsou, Director, Biological Resource Center of Institut Pasteur (CRBIP)

Scientist Feature: Dr. Robert Ben, Co-Founder and Chief Scientific Officer

PanTHERA CryoSolutions sat down with Dr. Robert Ben, Chief Scientific Officer of PanTHERA CryoSolutions to hear his thoughts on cryopreservation...
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Scientist Feature: Dr. Robert Ben, Co-Founder and Chief Scientific Officer

What are some of the challenges in cryopreservation?

What are some of the challenges in cryopreservation? Biopreservation is a process by which the degradation of biologics is suppressed...
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What are some of the challenges in cryopreservation?

Protected: Scientist Feature: Dr Erik Woods, Chief Science Officer, Co-Founder of Ossium Health

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Protected: Scientist Feature: Dr Erik Woods, Chief Science Officer, Co-Founder of Ossium Health

What are some of the applications of cryopreservation?

What are some of the applications of cryopreservation? Cryopreservation refers to the storage of biological material at low temperatures, and...
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What are some of the applications of cryopreservation?

Scientist Feature: Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions

We sat down with Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions and understood the motivations behind embarking on...
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Scientist Feature: Dr. Jason Acker, co-Founder and CEO of PanTHERA CryoSolutions

What is Cryopreservation?

What is Cryopreservation? Cryopreservation uses very low temperatures to preserve living cells and structurally intact tissues. While this imagery evokes...
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What is Cryopreservation?

Recovery and reproduction of an Antarctic tardigrade retrieved from a moss sample frozen for over 30 years

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Recovery and reproduction of an Antarctic tardigrade retrieved from a moss sample frozen for over 30 years

Vitrifying multiple embryos in different arrangements does not alter the cooling rate

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Vitrifying multiple embryos in different arrangements does not alter the cooling rate

A Novel Iterative Fitting Method

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A Novel Iterative Fitting Method